Sentries don't hit as hard as either of their fellow Act I Elites, but compensates by shuffling a bunch of Dazes into your discard pile. And if you try to block? It has an ability that raises its Strength for every Skill card you use. Not only does it hit hard from the jump, but it'll also constantly make you vulnerable in order to hit you even harder. Gremlin Nob is also a potential run-ender, especially on Ascension. The one mercy you're given is that Lagavulin starts asleep until it loses HP or three turns have passed, giving you time to prepare Powers and buffs/debuffs but if you encounter it during the "Dead Adventurer" event, it's awake from the get-go. Unless you got particularly lucky with your card choices (or you're playing as Silent and you poison/block it to death), prepare to have your life get slashed in half from this fight alone. 
Dealing 18 damage two turns in a row is already rather dangerous (and that's its base strength, not taking Ascension bonuses into account), but every third turn, it reduces your Strength and Dexterity by one, so playing a long defensive game is discouraged even further.
Lagavulin is probably the roughest Elite you can get. Demonic Spiders: Pretty much every Elite enemy in the game is this, although you do get rewarded with a Relic if you come out on top. The reception for this is quite mixed, as some players find it boring to build toward Frost orb games after games just to win a run. Made worse that a Frost orb build is regarded as the only reliable way to win on higher Ascension. However, due to this game's roguelike nature and scarceness of healing options, most players prefer to build toward Frost orb for its ability to grant block. Complacent Gaming Syndrome: The Defect has 4 types of orbs to play with. Characters who survive up to Act 3 can usually take down the boss with ease - and Mind Bloom's menacing tone reflects that perfectly. If the player chooses "I am War", they fight a boss from Act 1 for a Rare Relic. This track only plays during the event of the same name in Act 3. Mind Bloom, a Dark Reprise of The Guardian Emerges, the first boss theme. 
Awesome Music: The Heart, which plays during the fight with the True Final Boss.
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